gene_symbol
CD7
hgnc_id
HGNC:1695
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD7-specific CAR T cells bind CD7 on target cells, become activated via CD3zeta/co-stimulatory signaling, form an immunologic synapse, and directly lyse CD7+ cells through perforin/granzyme release (with additional death-receptor and cytokine-mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MHC-independent CAR recognition of a T-lineage cell-surface antigen on malignant T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06849921
disease_id_num_tar_ref
215
drug_id_num_tar_ref
595