gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CLDN18.2 on tumor cells, receive activation (with NKG2D co-stimulation), and kill via T-cell cytolysis (perforin/granzyme-mediated apoptosis, plus death-receptor pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
isoform 2-specific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05837299
disease_id_num_tar_ref
2061
drug_id_num_tar_ref
5511