gene_symbol
MICB
hgnc_id
HGNC:7091
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MICB (an NKG2D ligand) provides co-stimulatory engagement of the NKG2D module, enhancing activation and cytotoxicity of the CAR-T against CLDN18.2-positive cells; MICB expression alone does not trigger direct killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05837299
disease_id_num_tar_ref
2061
drug_id_num_tar_ref
5511