gene_symbol
ULBP2
hgnc_id
HGNC:14894
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IMC008 CAR-T cells execute cytolysis upon CAR engagement of CLDN18.2. The NKG2D-based module binds ULBP2 only to provide co-stimulation, enhancing activation but not conferring killing of ULBP2+ cells by itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05837299
disease_id_num_tar_ref
2061
drug_id_num_tar_ref
5511