gene_symbol
TNFRSF9
hgnc_id
HGNC:11924
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
4-1BB (CD137) on T cells is costimulated by the CAR T cell–expressed 4-1BB ligand; it is not a killing target. Cytotoxicity is directed at B7-H3–positive tumor cells via CAR-triggered T-cell perforin/granzyme-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
costimulatory receptor on T cells engaged by membrane 4-1BB ligand expressed on the product
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05835687
disease_id_num_tar_ref
2063
drug_id_num_tar_ref
5515