gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Isatuximab binds CD38 on target cells and induces Fc-mediated killing (ADCC, CDC, ADCP) and can trigger direct apoptosis of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ectoenzyme (NADase/cyclase) activity inhibited; Fc-mediated ADCC/CDC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06648889
disease_id_num_tar_ref
2066
drug_id_num_tar_ref
5520