gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CLDN18.2 ADC binds Claudin 18.2, is internalized, and releases MMAE, which inhibits tubulin to cause G2/M arrest and apoptosis; the antibody Fc can also mediate ADCC/CDC against CLDN18.2-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Tight junction protein; stomach-specific isoform expressed on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06519591
disease_id_num_tar_ref
14
drug_id_num_tar_ref
31