gene_symbol
CD7
hgnc_id
HGNC:1695
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD7 CAR T cells recognize CD7 on target cells and kill them via T-cell effector functions, primarily perforin/granzyme-mediated cytolysis and death receptor signaling.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary CAR antigen on malignant T cells; CD7 is also knocked out in BEAM-201 cells to prevent fratricide.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05885464
disease_id_num_tar_ref
2073
drug_id_num_tar_ref
5542