gene_symbol
PDCD1
hgnc_id
HGNC:8760
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
PD-1 is not a cytotoxic target of BEAM-201; PDCD1 (PD-1) is knocked out in the CAR T cells to prevent inhibition. BEAM-201 kills CD7-expressing cells via CAR engagement of CD7 and T-cell cytotoxic mechanisms (perforin/granzyme), not via PD-1.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Genetically disrupted in BEAM-201 cells to reduce checkpoint inhibition.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05885464
disease_id_num_tar_ref
2073
drug_id_num_tar_ref
5542