gene_symbol
TRAC
hgnc_id
HGNC:12029
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TRAC is not targeted for killing; it is knocked out in the CAR T cells to remove their endogenous TCR. BEAM-201 kills CD7-expressing cells via CAR-mediated T-cell cytotoxicity (perforin/granzyme).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Genetically disrupted to eliminate endogenous TCR and reduce GVHD risk.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05885464
disease_id_num_tar_ref
2073
drug_id_num_tar_ref
5542