gene_symbol
CD52
hgnc_id
HGNC:1804
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
BEAM-201 CAR-T cells target CD7, not CD52. CD52 is knocked out in the CAR-T cells to resist anti-CD52 conditioning (alemtuzumab); any killing of CD52+ cells is due to alemtuzumab, not BEAM-201.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Genetically disrupted to confer resistance to alemtuzumab during lymphodepletion.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05885464
disease_id_num_tar_ref
2073
drug_id_num_tar_ref
5542