gene_symbol
CD52
hgnc_id
HGNC:1804
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Alemtuzumab binds CD52 on leukocytes and triggers complement-dependent cytotoxicity and Fc receptor–mediated antibody-dependent cellular cytotoxicity by NK cells/macrophages, lysing CD52+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored glycoprotein on lymphocytes; IgG1 Fc engagement mediates CDC/ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05885464
disease_id_num_tar_ref
2073
drug_id_num_tar_ref
5545