gene_symbol
SDC1
hgnc_id
HGNC:10658
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD138 IgG1 binds CD138 on tumor cells; tumor proteases unmask the fused IFN-alpha, enabling local IFNAR engagement and JAK/STAT signaling that induces antiproliferative/apoptotic death. The IgG1 Fc can also recruit immune effectors to mediate ADCC/CDC against CD138+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated heparan sulfate proteoglycan
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06582017
disease_id_num_tar_ref
2080
drug_id_num_tar_ref
5561