gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD138 on tumor cells. Its IgG1 Fc engages CD16a on NK cells to drive ADCC against CD138+ cells, and unmasked IFN-α signals via IFNAR to induce tumor cell apoptosis. CD16a-expressing cells (NK cells) are engaged as effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06582017
disease_id_num_tar_ref
2080
drug_id_num_tar_ref
5561