gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
QXL138AM targets CD138, not C1q. After binding CD138, tumor proteases unmask IFN-α, which signals via IFNAR to induce apoptosis and growth arrest; the IgG1 Fc can recruit ADCC/CDC (via C1q) against CD138+ cells. Cells expressing C1q are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
C1q complex (C1QA/C1QB/C1QC) binds IgG1 Fc to initiate CDC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06582017
disease_id_num_tar_ref
2080
drug_id_num_tar_ref
5561