gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-TROP2 ADC binds TROP2, is internalized, and releases SN-38 (topoisomerase I inhibitor) causing topo I–DNA complex stabilization, DNA damage, replication arrest, and apoptosis; may also produce a bystander effect.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface glycoprotein; ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05928780
disease_id_num_tar_ref
2093
drug_id_num_tar_ref
5587