gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds MET on target cells, is internalized, linker cleavage releases MMAE, which inhibits tubulin polymerization leading to G2/M arrest and apoptosis (with potential bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06093503
disease_id_num_tar_ref
2106
drug_id_num_tar_ref
5633