gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases a topoisomerase I inhibitor (DXd) that causes DNA damage and apoptosis; Fc-mediated ADCC and a bystander effect further kill HER2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody binds extracellular domain; enables ADC internalization and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05982678
disease_id_num_tar_ref
2117
drug_id_num_tar_ref
5666