gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages Fcγ receptor–bearing effector cells (e.g., NK cells, macrophages) to mediate ADCC against EGFR-expressing cells; may also trigger complement-dependent lysis, while EGFR blockade is mainly antiproliferative.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; blocks EGF/TGF-alpha binding and receptor activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06309043
disease_id_num_tar_ref
2119
drug_id_num_tar_ref
5669