gene_symbol
CLEC12A
hgnc_id
HGNC:31713
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CLL-1 (CLEC12A)-targeted CAR T cells bind CLEC12A on target cells and induce MHC-independent T-cell cytolysis via perforin/granzyme (and apoptotic pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as MICL; cell-surface C-type lectin-like receptor on myeloid leukemia stem cells and blasts; CAR binding is MHC-independent
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06849921
disease_id_num_tar_ref
215
drug_id_num_tar_ref
601