gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and engages Fcγ receptor–bearing effectors (e.g., NK cells) to mediate ADCC, with possible CDC; signaling blockade is largely cytostatic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocks EGF/TGF-α binding and receptor activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06309043
disease_id_num_tar_ref
2119
drug_id_num_tar_ref
5670