gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cetuximab’s Fab binds EGFR on tumor cells; its IgG1 Fc engages FcγRI (CD64) on immune effector cells to drive ADCC/ADCP against EGFR+ targets. CD64-expressing cells are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity Fc interaction on monocytes/macrophages; may contribute to effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06309043
disease_id_num_tar_ref
2119
drug_id_num_tar_ref
5670