gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Nectin-4 on tumor cells, is internalized, and releases MMAE, which binds beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis. Killing is directed by Nectin-4 expression, not by beta-tubulin expression itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds beta-tubulin and inhibits polymerization, causing G2/M arrest
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05879653
disease_id_num_tar_ref
2121
drug_id_num_tar_ref
5676