gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds Trop-2, is internalized, and releases SN-38 (topoisomerase I inhibitor) intracellularly, causing DNA damage, replication arrest, and apoptosis; the membrane-permeable payload can also cause bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface transmembrane glycoprotein targeted by ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06236269
disease_id_num_tar_ref
2139
drug_id_num_tar_ref
5714