gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CD22, is internalized, and releases calicheamicin that induces DNA double-strand breaks, triggering apoptosis in CD22+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface receptor; ADC binding triggers internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06087419
disease_id_num_tar_ref
2144
drug_id_num_tar_ref
5724