gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD22 (not DNA) on B cells, is internalized, then releases calicheamicin that binds the DNA minor groove to cause double-strand breaks and apoptosis; DNA minor groove is the payload’s intracellular site, not the targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin payload binds sequence-specifically to the DNA minor groove to induce double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06087419
disease_id_num_tar_ref
2144
drug_id_num_tar_ref
5724