gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
KIR-based anti-mesothelin CAR T cells bind mesothelin and, via DAP12 ITAM signaling, kill target cells through T-cell cytotoxic mechanisms (perforin/granzyme and apoptosis pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPI-anchored glycoprotein; tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06377202
disease_id_num_tar_ref
2149
drug_id_num_tar_ref
5732