gene_symbol
TRPV6
hgnc_id
HGNC:14006
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CBP-1019 binds TRPV6 on tumor cells, is internalized, and releases the exatecan payload, a topoisomerase I inhibitor, causing DNA replication blockade and apoptosis of TRPV6-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface ion channel; internalization target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06576037
disease_id_num_tar_ref
2153
drug_id_num_tar_ref
5748