gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CBP-1019 targets FRa/TRPV6 on tumor cells for internalization, then releases exatecan that inhibits DNA topoisomerase I, halting DNA replication and triggering apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload enzyme target (exatecan/topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06576037
disease_id_num_tar_ref
2153
drug_id_num_tar_ref
5748