gene_symbol
PVRL4
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds Nectin-4, is internalized, and releases MMAE, which inhibits microtubule polymerization causing G2/M arrest and apoptosis of the target cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface adhesion molecule; ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06305767
disease_id_num_tar_ref
2165
drug_id_num_tar_ref
5790