gene_symbol
TNF
hgnc_id
HGNC:11892
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infliximab binds transmembrane TNF on activated immune cells; its IgG1 Fc recruits effector functions (ADCC/CDC) and triggers reverse signaling through tmTNF, inducing apoptosis of TNF-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both soluble and transmembrane TNF-alpha (tmTNF) to block TNFR1/2 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05660746
disease_id_num_tar_ref
2199
drug_id_num_tar_ref
5885