gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
PSMA CAR-T cells bind PSMA on target cells and induce T-cell cytotoxicity, primarily via perforin/granzyme-mediated apoptosis (and Fas–FasL), leading to lysis of PSMA-positive cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface extracellular domain; HLA-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05656573
disease_id_num_tar_ref
2203
drug_id_num_tar_ref
5896