gene_symbol
IL15RA
hgnc_id
HGNC:5978
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Anti-CD19 CAR-NK cells recognize CD19 and kill CD19+ B cells via CAR-triggered NK effector mechanisms (perforin/granzymes). IL-15Rα is not targeted; IL-15/IL-15Rα signaling only supports NK activation/persistence.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity binding site for IL-15; supports autocrine/paracrine IL-15 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06707259
disease_id_num_tar_ref
1
drug_id_num_tar_ref
1