gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
LM-302 targets CLDN18.2 on tumor cells, is internalized, and releases MMAE; the payload then binds the vinca site on beta-tubulin to inhibit microtubule polymerization, causing G2/M arrest and apoptosis (ADCC/CDC may also contribute). Beta-tubulin is not the targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of the MMAE payload; inhibition of microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06519591
disease_id_num_tar_ref
14
drug_id_num_tar_ref
31