gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and recruits FcγR-expressing immune effectors (e.g., NK cells) to mediate ADCC; HER2 signaling blockade may also induce apoptosis.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain II (dimerization interface)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06439693
disease_id_num_tar_ref
2209
drug_id_num_tar_ref
5913