gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells, is internalized, and releases the DXd topoisomerase I inhibitor, causing DNA damage/replication arrest and apoptosis; it also mediates Fc-dependent ADCC and bystander killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component binds extracellular domain IV; mediates internalization and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06439693
disease_id_num_tar_ref
2209
drug_id_num_tar_ref
5915