gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not Top1), is internalized, and releases the DXd payload that inhibits Top1 to cause DNA damage and apoptosis (with ADCC and bystander effects). Top1 expression alone does not make cells directly targeted by the drug.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DXd payload inhibits Top1-DNA cleavage complex to block DNA replication
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06439693
disease_id_num_tar_ref
2209
drug_id_num_tar_ref
5915