gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 and is internalized; lysosomal processing releases the DM1 payload, a microtubule inhibitor, causing mitotic arrest and apoptosis in HER2+ cells (with additional ADCC from trastuzumab).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab binds extracellular domain IV epitope on HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06439693
disease_id_num_tar_ref
2209
drug_id_num_tar_ref
5916