gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
T-DM1 targets HER2 on the cell surface; after HER2-mediated internalization, DM1 is released and binds beta-tubulin to disrupt microtubules, causing mitotic arrest and apoptosis. Beta-tubulin itself is not the targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DM1 payload binds beta-tubulin (maytansine site) to inhibit microtubule assembly
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06439693
disease_id_num_tar_ref
2209
drug_id_num_tar_ref
5916