gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CEA-targeted CAR-T cells bind CEACAM5 on tumor cells, trigger CD3ΞΆ/co-stimulatory activation, and kill via perforin/granzyme-mediated cytolysis and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPI-anchored glycoprotein overexpressed on many adenocarcinomas
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06821048
disease_id_num_tar_ref
223
drug_id_num_tar_ref
623