gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Endogenous TCRs on infused neoantigen-specific CD8+ T cells recognize the patient-specific peptide presented on HLA-A*11:01 and kill target cells via perforin/granzyme-mediated cytolysis (± Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class I complex recognized by endogenous TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05798533
disease_id_num_tar_ref
2219
drug_id_num_tar_ref
5943