gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Adoptively transferred TILs recognize the neoantigen peptide–HLA class I complex via native TCRs and directly lyse the presenting cell through perforin/granzyme-mediated cytotoxicity (and death-receptor pathways), with cytokines such as IFN-γ/TNF augmenting killing.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class I complex (HLA-A/B/C); recognized by CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06613152
disease_id_num_tar_ref
2223
drug_id_num_tar_ref
5956