gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous TILs recognize the neoantigen–HLA class II complex via native TCRs (primarily CD4+ T cells) and directly kill target cells through perforin/granzyme release and death-receptor pathways, with IFN-γ/TNF further promoting apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class II complex (HLA-DR/DP/DQ); recognized by CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06613152
disease_id_num_tar_ref
2223
drug_id_num_tar_ref
5956