gene_symbol
CD52
hgnc_id
HGNC:1804
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Alemtuzumab binds CD52 on leukocytes and induces complement-dependent cytotoxicity and Fc-mediated ADCC (and phagocytosis), leading to lysis/depletion of CD52+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell surface glycoprotein on lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06872333
disease_id_num_tar_ref
225
drug_id_num_tar_ref
629