gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2, blocks HER2 dimerization and survival signaling to induce apoptosis, and its Fc engages Fcγ receptor–bearing immune cells to mediate ADCC against HER2-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular dimerization domain (subdomain II) to block HER2 heterodimerization, especially HER2/HER3
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05980208
disease_id_num_tar_ref
2225
drug_id_num_tar_ref
5964