gene_symbol
DLK1
hgnc_id
HGNC:2907
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After binding DLK1, the ADC is internalized and linker cleavage releases a PBD dimer that creates DNA interstrand cross-links, blocking replication and killing the DLK1-expressing cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface non-canonical Notch ligand (EGF-like protein)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06041516
disease_id_num_tar_ref
2238
drug_id_num_tar_ref
5991