gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds EGFR (and HER3) on tumor cells, is internalized, and releases the topoisomerase I inhibitor brengitecan, causing DNA strand breaks and cell death, with bystander killing of nearby cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor; bispecific ADC antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06343948
disease_id_num_tar_ref
2241
drug_id_num_tar_ref
5997