gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG binds CD38 on target cells; the Fc region engages NK cells/macrophages and complement to mediate ADCC, ADCP, and CDC, and can also trigger apoptosis, resulting in depletion of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane CD38; binding may inhibit ecto-enzyme activity and trigger ADCC/CDC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05694767
disease_id_num_tar_ref
2242
drug_id_num_tar_ref
6002