gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
After phosphorylation by HSV‑1 thymidine kinase, ganciclovir triphosphate inhibits DNA polymerase and causes DNA chain termination, blocking DNA synthesis and killing the activated (HSV‑TK–expressing) cells, with a bystander effect on neighbors.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibited by ganciclovir triphosphate during DNA synthesis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06695026
disease_id_num_tar_ref
2243
drug_id_num_tar_ref
6004