gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
B7-H3–targeted CAR-γδ T cells bind B7-H3 on target cells and, upon CAR signaling, directly kill them via T-cell cytotoxicity (perforin/granzyme release and death-receptor pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface immune checkpoint (IgSF) targeted by CAR scFv; MHC-independent recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06592092
disease_id_num_tar_ref
2252
drug_id_num_tar_ref
6026